Cephalic hypersensitivity syndrome:

A revolutionary approach to healing chronic illness syndrome

Kosuke Oota. DMSc.

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Table of contents


Part 1. Chapter 1

What is Cephalic Hypersensitivity Syndrome?


1. Why I am proposing the concept of cephalic hypersensitivity syndrome

Recognition of the name "cephalic hypersensitivity syndrome" in medical association guidelines

Cephalic hypersensitivity syndrome represents the aggravation of indefinite complaints to the point at which it impedes everyday activities

The Ministry of Health, Labour and Welfare is concerned about chronic pain and indefinite complaints


2. The true identity of cephalic hypersensitivity syndrome

The body's homeostasis is protected by the autonomic nerves and hormones

Circadian and seasonal variation in hormones

Sympathetic nerves and cephalic hypersensitivity syndrome

Autonomic dysregulation is serotonin dysregulation

The most important brain hormones

Cephalic hypersensitivity syndrome is caused by the dysregulation of the hormone-nerve system


3. Why does cephalic hypersensitivity syndrome develop?

What sort of person is likely to develop cephalic hypersensitivity syndrome? 

Laboratory test results are not the be-all and end-all

Problems with the reference values for laboratory test results formulated by medical associations

Iatrogenic cephalic hypersensitivity syndrome from over-medication

Summary – how to maintain a balanced relationship with medications


4. Diagnosis of cephalic hypersensitivity syndrome


5. Treatment of cephalic hypersensitivity syndrome

Illustration of my treatment algorithm

The "three arrows" supporting the cephalic hypersensitivity syndrome treatment algorithm

The first arrow: Improving lifestyle: Taking back your own health for yourself

The second arrow: Improving thinking: The only person who can change you is yourself

The third arrow: Night therapy: Small doses of medication are effective if taken at night 


6. Drug treatment for cephalic hypersensitivity syndrome

  • Antiepileptics
  • Antidepressants
  • Kingdom of effective drugs
  • My coded prescriptions


7. Prognosis for treatment: Types of prognosis and future issues

Evidence for cephalic hypersensitivity syndrome: Inquiring into the truth of natural science


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Part1.Chapter 2

Disorders that can easily develop into cephalic hypersensitivity syndrome


1. Headache

Medical interview for headache

Association with exercise, bathing, menstruation, and alcohol

Diverse migraine-associated symptoms

Differentiating migraine and tension headache is difficult in clinical practice

Chronic daily headache is actually cephalic hypersensitivity syndrome

The increasing number of children with migraine


2. Dizziness / vertigo

Migraine-associated vertigo is an internationally recognized condition

Medical interviews for dizziness / vertigo

Try using special maneuvers to improve vertigo


3. Tinnitus: Characteristics of tinnitus associated with cephalic

hypersensitivity syndrome

Medical Interview for Tinnitus

Tinnitus treatment

Headache, Dizziness / Vertigo, and Tinnitus: The Spectrum of Symptoms


4. Headache, dizziness / vertigo, and stiff shoulders caused by straight neck


5. Headache and stiff shoulders caused by eyestrain


Computer vision syndrome


6. Sleep disorders: Can't sleep at night, but sleepy during the day

Sleep-related medical interview

Dealing with sleep disorders in everyday life

Why it's so important to get up and go to bed early

A rising number of children have cephalic hypersensitivity syndrome: The amount of time children spend sleeping is decreasing at a frightening rate 


7. Restless Legs Syndrome (RLS)


8. Periodic Limb Movement Disorder (PLMD)

The mysterious relationship between restless legs syndrome and periodic limb movement disorder


9. Allodynia unrelated to migraine


10. Chronic lower back pain: Muscle stiffness due to static muscle load



11. Myofascial pain syndrome


12. Chronic constipation: The retention of toxins in the body

Dealing with chronic constipation: The miraculous power of enemas


13. Chronic fatigue: The accumulation of toxins in the mind

Fatigue is a red light to protect the body

Cephalic hypersensitivity syndrome and chronic fatigue


14. Disorders that are difficult to distinguish from cephalic

  • hypersensitivity syndrome
  • Fibromyalgia (FM)
  • Chronic fatigue syndrome
  • Menopausal syndrome


Conclusion: The chronic illness syndrome of cephalic hypersensitivity syndrome is a form of mental chronic pain

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Part1.Chapter 3

The mechanism of cephalic hypersensitivity syndrome: Theoretical predictions from observations


Hypothesis 1: Many of the chronic illness syndromes suffered by patients are caused by cephalic hypersensitivity syndrome

Yunus' concept of Central sensitivity syndrome (CSS)

Definition of central sensitivity syndromes

Historical development of the concept of central sensitivity syndromes 

From fibromyalgia to central sensitivity syndromes: Clinical significance

My own concept of "cephalic hypersensitivity syndrome" and Yunus' central sensitivity syndromes


Hypothesis 2: Cephalic hypersensitivity syndrome can be explained in terms of the molecular biology of synaptic plasticity

My inferences concerning ion channels and brain hormones

The choice of the easiest medication for individuals to take: Finnerup et al.'s work 

Medications for treating cephalic hypersensitivity syndrome and the molecular biology of synaptic plasticity


Hypothesis 3: A biopsychosocial model is appropriate for the treatment of cephalic hypersensitivity syndrome

The biopsychosocial model

Cognitive behavioral therapy


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Part 2.

Treatment of cephalic hypersensitivity syndrome: case reports


Case 1 : A 46-year-old woman suffering from stiff shoulder for many years


Case 2 : A 40-year-old man whose ability to work was affected by stiff shoulder and hand numbness


Case 3 : A 70-year-old woman suffering from alleged depression for three years


Case 4 : An 8-year-old boy unable to concentrate during lessons due to excessive daytime sleepiness


Case 5 : A 23-year-old woman whose daily life was affected by falling asleep during meetings even when she was standing and sometimes walking, who was unable to drive due to fear of falling asleep, and who became confused


Case 6 : A 12-year-old girl with symptoms of headaches and vomiting from infancy and recent tingling and numbness in the right hand


Case 7 : A 74-year-old man with confusional arousals who shouted and walked around at night


Case 8 : A 16-year-old girl with “monster headaches” that dramatically improved with a novel antiepileptic


Case 9 : A 10-year-old girl unable to sleep due to headaches and restless legs


Case 10 : A 34-year-old man who wanted to try subcutaneous injections after a diagnosis of cluster headache


Case 11 : A 41-year-old woman with repeated episodes of headaches that persist for one month then resolve as if they had never happened


Case 12 : A 37-year-old woman effectively treated with oral drugs after a diagnosis of cluster headache, which is rare in women


Case 13 : A 59-year-old woman suffering from numbness in her limbs for four years


Case 14 : A 43-year-old man with cluster headache originally misdiagnosed as trigeminal neuralgia (facial neuralgia)


Case 15 : A 10-year-old boy with sleep apnea syndrome originally misdiagnosed as attention deficit hyperactivity disorder (ADHD)


Case 16 : A 66-year-old woman unable to carry a shoulder bag due to tingling mid and upper back pain


Case 17 : A 46-year-old woman with generalized pain diagnosed as fibromyalgia that was refractory to treatment


Case 18 : A 46-year-old woman suffering from headaches for nearly 20 years who was astonished when they resolved


Case 19 : A 75-year-old man unable to sleep due to recurrent stomach pain that did not resolve despite treatment at various hospitals


Case 20 : A 69-year-old woman suffering from diverse symptoms that prevented her from even doing the cooking


Case 21 : A 68-year-old man struggling with tinnitus for over a decade


Case 22 : A 62-year-old woman suffering from whole-body pain


Case 23 : A 71-year-old woman troubled by severe headaches that did not respond to even powerful drugs


Case 24 : A 48-year-old man with severe rotational vertigo and tinnitus


Case 25 : A 61-year-old woman unable to keep her balance


Case 26 : A 38-year-old woman unable to sleep at night for two years due to restlessness


Case 27 : A 50-year-old woman suffering from headaches for over 20 years causing her to finally take leave from work


Case 28 : A 46-year-old woman with vertigo with dizziness and wobbliness that affected her ability to work for six years


Case 29 : A 42-year-old woman whose headaches and vertigo improved beyond expectations


Case 30 : A 38-year-old woman unable to ride in a car or on a bicycle


Case 31 : A 76-year-old man nearly gave up driving


Case 32 : A 74-year-old woman unable to greet others or cross the road


Case 33 : A 70-year-old man suffering from lack of sleep due to 20 years of restless legs


Case 34 : A 40-year-old man with probable dysthymia initially suspected to be cephalic hypersensitivity syndrome


Case 35 : A 66-year-old man suffering for five years from sleeplessness and bizarre climbing motions while sleeping


Case 36 : A 58-year-old man suffering from 20 years of chronic lower back pain, 10 years of sleeplessness and constipation, and six years of stomach and mid- and upper back pain, and anorexia


Case 37 : A 55-year-old man who began behaving strangely in his sleep after taking a drug for trigeminal neuralgia


Case 38 : A 67-year-old man with a sensation like mice running round in his stomach, no appetite, and who was unable to sleep


Case 39 : A 61-year-old man suffering from unpleasant sensations in the throat and tongue and numbness around the tip of the tongue


Case 40 : A 60-year-old man suffering from generalized pain for many years


Case 41 : A 38-year-old woman with epilepsy complicated by hysterical seizures whose convulsive seizures, from which she had suffered for many years, resolved after receiving a diagnosis of just epilepsy (with no mention of hysteria), making it easier for her to get married


Case 42 : A 55-year-old man suffering from feeling unsteady and slurred speech for five years



About the cephalic hypersensitivity syndrome hotline

About the author: who is Kosuke Oota?

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Brief Author Bio

Kosuke Oota graduated from Okayama University Medical School in 1964 and completed his doctorate at Okayama University Graduate School in 1969. After working as Chief of Neurosurgery at National Fukuyama Hospital (now called National Hospital Organization Fukuyama Medical Center), in 1976, he established Oota Hospital, now known as the Brain Attack Center Oota Memorial Hospital. In 1986, he developed a wide-area emergency medical network using Oota CT image data transmission devices in coordination with medical facilities in isolated islands and remote mountainous areas without on-site neurosurgeons. He is a recipient of the Japan Medical Association’s highest merit award as well as a Congress of Cell Transplant Society prize for his active work in kidney and cornea donation from deceased donors. In his roles as clinical professor at Okayama University Medical School and primary researcher at the Shibuya Longevity Health Foundation, his research interests cover cerebrovascular disease, sleep disorders, and cephalic hypersensitivity syndrome.


  • MR angiography: basics to clinical application. An easy to understand guide.
    Axel Springer Japan Publishing (1991)
  • My epilepsy outpatient clinic: an introductory handbook. Fukuyama Transporting
    Shibuya Longevity Health Foundation (2012)
  • Increasing incidence of cephalic sensitivity dizziness / vertigo at my dizziness /
  • vertigo outpatient clinic. 2nd edition.
    -Fukuyama Transporting Shibuya Longevity 
    Health Foundation (2012)
  • Cephalic hypersensitivity syndrome is on the rise: testimonials from 36 people

finally cured of this condition. Shibuya Longevity Health Foundation (2013)